Why the study?
The prognostic value of the SYNTAX score for long-term outcomes and differences in prognosis between medical therapy and PCI across SYNTAX score strata in unstable angina pectoris were not well known in the modern era.
Does percutaneous coronary intervention reduce long-term major adverse cardiovascular events compared to medical therapy in patients with unstable angina pectoris stratified by SYNTAX score?
Does percutaneous coronary intervention reduce long-term major adverse cardiovascular events compared to medical therapy in patients with unstable angina pectoris stratified by SYNTAX score?
In patients with unstable angina pectoris, percutaneous coronary intervention significantly reduces long-term MACEs and cardiac death compared to medical therapy only in those with high SYNTAX scores (≥33), but not in those with low or medium scores.
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Should not yet alter unstable angina management by SYNTAX score; leaves open randomized confirmation of benefit in high-complexity disease.
Xu et al. (2022) studied this question.
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