Why the study?
Although NAFLD is linked to atherosclerotic disease, the relationships between coronary atherosclerosis severity and pathologic findings in NAFLD remain unknown.
Is non-alcoholic steatohepatitis (NASH) associated with more severe coronary artery lesions compared to non-alcoholic fatty liver in patients with NAFLD?
Population
101 patients with liver biopsy-proven NAFLD and chest pain or ECG abnormalities
Comparison
NASH vs non-alcoholic fatty liver
Design
Observational study
Authors
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Supports closer CAD monitoring in NASH; extends cross-sectional associations but leaves causality and practice change open.
Is non-alcoholic steatohepatitis (NASH) associated with more severe coronary artery lesions compared to non-alcoholic fatty liver in patients with NAFLD?
Patients with NASH have more severe coronary artery lesions on CCTA compared to those with simple fatty liver, indicating a higher risk for coronary artery disease.
Niikura et al. (2020) studied this question.
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