Why the study?
Does tOPV compared to bOPV in supplemental immunization activities improve population immunity to poliovirus transmission and prevent cVDPV2 emergence?
Population
Simulated populations in a dynamic poliovirus transmission model of northwest Nigeria and an integrated…
Comparison
Trivalent oral poliovirus vaccine used in… vs Bivalent oral poliovirus vaccine used in SIAs
Design
Other
Authors
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Supports tOPV prioritization in SIAs to avert cVDPV2; modeling leaves open prospective confirmation before policy adoption.
Does tOPV compared to bOPV in supplemental immunization activities improve population immunity to poliovirus transmission and prevent cVDPV2 emergence?
Prioritizing tOPV over bOPV in supplemental immunization activities before OPV2 cessation is necessary to prevent serotype 2 circulating vaccine-derived poliovirus outbreaks without significantly compromising serotype 1 and 3 immunity.
Thompson et al. (2015) studied this question.
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