Key result
The withdrawal of tOPV and declining preventive bOPV campaigns reduced immunity to types 1 and 3 poliovirus in vulnerable areas and caused widespread loss of type 2 immunity.
Why the study?
Following tOPV withdrawal, preventive bOPV SIAs decreased while cVDPV2 outbreaks required targeted mOPV2 use, affecting expected population immunity.
Observational
The withdrawal of tOPV and reduced preventive SIAs have created significant gaps in population immunity to all poliovirus serotypes, particularly type 2, increasing the risk of outbreaks.
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May signal rising polio outbreak risk in vulnerable areas; leaves open optimal SIA strategies for immunity restoration.
Voorman et al. (2022) conducted an observational in Poliovirus immunity. Withdrawal of trivalent oral poliovirus vaccine (tOPV) vs. Pre-withdrawal period was evaluated on Population mucosal immunity to poliovirus types 1, 2, and 3. The withdrawal of tOPV and declining preventive bOPV campaigns reduced immunity to types 1 and 3 poliovirus in vulnerable areas and caused widespread loss of type 2 immunity.
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