Population
Sabin vaccine-derived field isolate of poliovirus type 1 (17 plaques isolated from the strain)
Comparison
Phenotypic and genetic analysis including… vs Sabin 1 strain and wild-type poliovirus
Design
Preclinical
Authors
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Alerts to antigenic variation in VDPV isolates; leaves open human relevance and surveillance needs.
A Sabin vaccine-derived poliovirus type 1 isolate displayed aberrant phenotypic features and a deletion in antigenic site 1, though standard polio vaccination still protects against it.
Mulders et al. (1999) studied this question.
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