September 1, 2002AJP Heart and Circulatory Physiology

Altered dose response to β-agonists in SERCA1a-expressing hearts ex vivo and in vivo

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Population

Transgenic hearts expressing sarcoplasmic reticulum Ca-ATPase1a and wild-type hearts

Comparison

Beta-adrenergic stimulation vs Wild-type (WT) hearts

Design

Preclinical

Authors

SHSabine HukeUniversity of Alabama at Birmingham VPVikram PrasadCincinnati Children's Hospital Medical Center MNMichelle L. NiemanCincinnati Children's Hospital Medical Center

Discussion

Member takes

Implication

Blunted beta-adrenergic reserve despite higher baseline function in transgenic hearts; leaves open translational relevance of SERCA modulation to human HF.

Structured PICO

Population

Transgenic (TG) hearts expressing sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA)1a and wild-type (WT) hearts

Intervention

Beta-adrenergic stimulation (isoproterenol ex vivo, dobutamine in vivo)

Comparator

Wild-type (WT) hearts

Outcome

Contractile characteristics (maximal rates of contraction and relaxation) and response to beta-adrenergic stimulationsurrogate

Increases in SERCA protein level alter the beta-adrenergic response and affect phospholamban phosphorylation, though overall in vivo cardiac function is only slightly enhanced.

Cite This Study

Huke et al. (2002) studied this question.

synapsesocial.com/papers/6a83822f48656d5c51fae586 https://doi.org/10.1152/ajpheart.00078.2002

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Implication

Blunted beta-adrenergic reserve despite higher baseline function in transgenic hearts; leaves open translational relevance of SERCA modulation to human HF.

Altered dose response to β-agonists in SERCA1a-expressing hearts ex vivo and in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Altered dose response to β-agonists in SERCA1a-expressing hearts ex vivo and in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider