Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia

Recent evidence highlights the importance of considering directional sensitivity in dynamic cerebral autoregulation. The current analysis found no directional sensitivity in the cerebral pressure-flow relationship during 0.03- and 0.10-Hz oscillatory lower body negative pressure in normothermia or moderate hyperthermia in healthy participants. However, reduced directional sensitivity metrics during moderate hyperthermia suggest that dynamic cerebral autoregulation may become more efficient under moderate heat stress.