Why the study?
Does clarithromycin treatment prolong the QTc interval in children with respiratory tract infections?
Does clarithromycin treatment prolong the QTc interval in children with respiratory tract infections?
Clarithromycin causes a modest but significant prolongation of the QTc interval in children, suggesting a potential need for ECG monitoring to detect drug-induced arrhythmias.
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Clarithromycin was associated with QTc prolongation in children; leaves open arrhythmia risk and monitoring needs.
UNLABELLED: The effect of clarithromycin on the QT interval was studied in a group of 28 children treated for respiratory tract infections. QTc was measured before and following 24 h of treatment. A modest (average 22 ms, 95% CI 14-30 ms) but significant QTc prolongation (p<0.001) was observed, with seven cases having a QTc >440 ms during treatment (including a single case with QTc >460 ms). CONCLUSION: Serial QTc measurements are necessary for early detection of children at risk for drug-induced arrhythmias.
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Germanakis et al. (2006) studied this question.
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