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August 22, 2011AJP Heart and Circulatory Physiology32 citationsOpen Access

Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion

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Why the study?

Does daltroban reduce the pressor response to static contraction and stretch in a rat model of peripheral artery disease?

Population

Decerebrate rats with femoral arteries ligated 72 h before the experiment and control rats whose hindlimbs…

Comparison

Femoral arterial injections of daltroban, a TP… vs Baseline and intravenous injections of daltroban

Design

Preclinical

Authors

ALAnna K. LealJMJennifer L. McCordHTHirotsugu Tsuchimochi

Discussion

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Overview

TP receptor blockade merits targeted study in PAD models; leaves open translation to human exercise pressor reflex.

Structured PICO

Does daltroban reduce the pressor response to static contraction and stretch in a rat model of peripheral artery disease?

P
Population
Decerebrate rats with femoral arteries ligated 72 h before the experiment (a model of simulated peripheral artery disease) and control rats whose hindlimbs were freely perfused
I
Intervention
Femoral arterial injections of daltroban (80 μg), a TP receptor antagonist
C
Comparator
Baseline (before injection) and intravenous injections of daltroban
O
Outcome
Pressor response to static contraction and stretchsurrogate

TP receptor blockade with daltroban attenuates the exaggerated exercise pressor reflex in a rat model of peripheral artery disease.

Cite This Study

Leal et al. (2011) studied this question.

synapsesocial.com/papers/6a83875a46a589022496094fhttps://doi.org/10.1152/ajpheart.00403.2011
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