Key result
Prostanoid TP receptor blockade with SQ29548 completely inhibited the acute pressor response to ET-1, with a change in MAP of -3% compared to 14% with vehicle (P<0.05).
Population
Male Sprague-Dawley rats anaesthetized with Inactin
Comparison
TP receptor antagonist SQ29548 prior to a 1 h… vs Vehicle (0.9% NaCl) prior to ET-1 infusion
Design
Preclinical
Follow-up
1 hour
Authors
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TP receptor blockade attenuates ET-1 pressor effects in rats; leaves open relevance to human hypertension.
Absolute Event Rate: -3% vs 14%
p-value: p=<0.05
In a rat model, TP receptor activation contributes to the acute pressor response to ET-1 but is not involved in its renal haemodynamic effects.
Williams et al. (2006) studied Pressor and intrarenal haemodynamic response to endothelin. TP receptor antagonist SQ29548 vs. Vehicle (0.9% NaCl) was evaluated on Change in mean arterial pressure (MAP) (p=<0.05). Prostanoid TP receptor blockade with SQ29548 completely inhibited the acute pressor response to ET-1, with a change in MAP of -3% compared to 14% with vehicle (P<0.05).
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