Evaluation of a New Antihypertensive Agent

July 4, 1980JAMA

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Key Points

To assess the therapeutic utility and safety profile of minoxidil in managing cases of severe hypertension resistant to standard treatments.
Evaluated oral administration of minoxidil in clinical regimens for severe hypertension.
Co-administered minoxidil with a diuretic and a beta-blocking agent to counteract anticipated physiological side effects.
Minoxidil acts as an orally effective, long-acting vasodilator that lowers blood pressure in severe hypertension refractory to conventional agents.
Fluid retention and hypertrichosis occur as the most frequent adverse drug reactions during therapy.

P

Population

Patients with severe hypertension that cannot be controlled by conventional therapy

I

Intervention

Minoxidil given with a diuretic and a beta-blocking drug

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Minoxidil is an orally effective vasodilator used in combination with a diuretic and beta-blocker for severe, refractory hypertension.

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Mary Ellen Kosman (1980) studied this question.

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