Why the study?
Does pretreatment with adrenergic neuron or ganglion blockers alter the vasodilatory effects of methylprednisolone and phenoxybenzamine during hemorrhagic shock in dogs?
Does pretreatment with adrenergic neuron or ganglion blockers alter the vasodilatory effects of methylprednisolone and phenoxybenzamine during hemorrhagic shock in dogs?
Methylprednisolone-induced vasodilation in hypovolemic shock with alpha-receptor blockade relies on intact noradrenaline release from postganglionic adrenergic nerve terminals.
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Highlights dependence on intact sympathetic terminals for steroid vasodilation in canine shock; leaves open human translation.
Haglund et al. (1980) studied this question.
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