Key result
Phenoxybenzamine alone or combined with massive doses of hydrocortisone altered hemodynamics and plasma catecholamines in dogs with hemorrhagic shock, showing no clear-cut relationship between them.
Why the study?
Does phenoxybenzamine alone or with hydrocortisone alter plasma catecholamine levels and hemodynamics in dogs with hemorrhagic shock?
Does phenoxybenzamine alone or with hydrocortisone alter plasma catecholamine levels and hemodynamics in dogs with hemorrhagic shock?
The study demonstrates complex and non-linear relationships between hemodynamic changes and plasma catecholamine kinetics during hypovolemic shock in a canine model.
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Phenoxybenzamine alters canine shock hemodynamics without clear catecholamine linkage; leaves open relevance to human hypovolemic shock.
Hellman et al. (1980) studied Hemorrhagic shock. Phenoxybenzamine and hydrocortisone vs. Predrug hypotension period was evaluated on Plasma adrenaline and noradrenaline levels, cardiac output, and heart rate. Phenoxybenzamine alone or combined with massive doses of hydrocortisone altered hemodynamics and plasma catecholamines in dogs with hemorrhagic shock, showing no clear-cut relationship between them.
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