Key result
Massive doses of dexamethasone combined with phenoxybenzamine were unable to increase peripheral blood flow in dogs subjected to hemorrhagic hypotension.
Why the study?
Does massive doses of dexamethasone combined with phenoxybenzamine increase peripheral blood flow in dogs with hemorrhagic hypotension?
Does massive doses of dexamethasone combined with phenoxybenzamine increase peripheral blood flow in dogs with hemorrhagic hypotension?
Dexamethasone does not induce vasodilation or increase peripheral blood flow in hypovolemic shock, suggesting its potential benefits are not due to direct vascular effects.
Does not support direct vasodilation by dexamethasone in hypovolemic shock; leaves open alternative mechanisms for any clinical benefit.
The hemodynamic effects of massive doses of dexamethasone in combination with the alpha-adrenergic blocking agent phenoxybenzamine were studied in dogs subjected to hemorrhagic hypotension. Previously it has been shown that the glucocorticoid methylprednisolone, but not the glucocorticoid betamethasone, induces a pronounced vasodilation in combination with phenoxybenzamine. In the present study it was found that also dexamethasone (a stereoisomer of betamethasone) is unable to increase the peripheral blood flow after phenoxybenzamine. Since equivalent doses were used in relation to glucocorticoid activity, it seems reasonable to conclude that the different hemodynamic patterns are unrelated to the glucocorticoid ability of the drugs. Furthermore, it is unlikely that possible beneficial effects of dexamethasone in hypovolemic shock are due to a direct vascular influence.
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Hellman et al. (1982) studied Hemorrhagic hypotension. Dexamethasone in combination with phenoxybenzamine was evaluated on Peripheral blood flow. Massive doses of dexamethasone combined with phenoxybenzamine were unable to increase peripheral blood flow in dogs subjected to hemorrhagic hypotension.
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