Why the study?
Does maprotiline improve depression and anxiety compared to diazepam in patients with acute myocardial infarction?
Population
n=126 patients in the early stages of acute myocardial infarction with emotional disturbances
Comparison
Maprotiline 25 mg orally twice daily for an… vs Diazepam 5 mg orally twice daily for an average…
Design
Other
Follow-up
average two weeks (ten days to eight weeks)
Authors
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Maprotiline may improve depression more than diazepam in early AMI; leaves open its preferred role pending randomized confirmation.
Does maprotiline improve depression and anxiety compared to diazepam in patients with acute myocardial infarction?
Maprotiline is effective and safe for managing depression in the early stages of acute myocardial infarction without inducing cardiotoxic signs.
Selvini et al. (1976) studied this question.
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