On the Quantitative Estimation of Prothrombin

Armand J. Quick

doi:10.1093/ajcp/15.12.560

December 1, 1945American Journal of Clinical Pathology

On the Quantitative Estimation of Prothrombin

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Key Points

To establish and standardize an accurate quantitative method for determining prothrombin concentrations in circulating blood plasma.
Measured plasma clotting time following the controlled addition of optimal calcium and excess thromboplastin.
Constructed standardized calibration curves relating clotting velocity directly to plasma prothrombin levels.
Demonstrated that plasma clotting time is inversely proportional to prothrombin concentration under standardized thromboplastin and calcium conditions.
Established a reproducible quantitative assay to detect hypoprothrombinemia and evaluate physiological coagulation capacity.

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Implication

Methodological study demonstrates quantitative estimation of prothrombin in plasma, highlighting standardized diagnostic assessment for coagulation disorders.

Abstract

Armand J. Quick; On the Quantitative Estimation of Prothrombin., American Journal of Clinical Pathology, Volume 15, Issue 12, 1 December 1945, Pages 560–566, ht

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Cite This Study

Armand J. Quick (1945) studied this question.

synapsesocial.com/papers/6a8388745608ade709cd7cc2 https://doi.org/10.1093/ajcp/15.12.560

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On the Quantitative Estimation of Prothrombin

Key Points

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Implication

Abstract

Discussion

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On the Quantitative Estimation of Prothrombin

Key Points

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Implication

Abstract

Discussion

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