Population
Smooth muscle cells of the guinea-pig portal vein
Design
Preclinical
Authors
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Should not alter clinical practice; leaves open endothelin’s role in human vascular Ca2+ regulation.
Endothelin augments voltage-dependent calcium channel currents in guinea-pig portal vein smooth muscle cells through indirect mechanisms, increasing the open probability of both nifedipine-sensitive and resistant channels.
Inoue et al. (1990) studied this question.
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