January 15, 1997Journal of NeuroscienceOpen Access

Pontine Nitric Oxide Modulates Acetylcholine Release, Rapid Eye Movement Sleep Generation, and Respiratory Rate

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Population

unanesthetized cats

Design

Preclinical

Authors

TLTimothy O. Leonard RLRalph LydicUniversity of Tennessee System

Discussion

Member takes

Implication

No clinical implications; leaves open whether pontine nitric oxide modulates human REM sleep or respiration.

Structured PICO

Population

unanesthetized cats

Intervention

Local nitric oxide synthase (NOS) inhibition by microdialysis delivery or microinjection of N(G)-nitro-L-arginine (NLA) into the medial pontine reticular formation (mPRF)

Outcome

Acetylcholine (ACh) release, amount of REM sleep, and respiratory ratesurrogate

In a feline model, nitric oxide in the medial pontine reticular formation modulates acetylcholine release, REM sleep duration, and respiratory rate.

Cite This Study

Leonard et al. (1997) studied this question.

synapsesocial.com/papers/6a83a4ee6eaad3b729ee7604 https://doi.org/10.1523/jneurosci.17-02-00774.1997

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Pontine Nitric Oxide Modulates Acetylcholine Release, Rapid Eye Movement Sleep Generation, and Respiratory Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pontine Nitric Oxide Modulates Acetylcholine Release, Rapid Eye Movement Sleep Generation, and Respiratory Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider