Role of Natriuretic Peptide Receptor Guanylyl Cyclase-A in Myocardial Infarction Evaluated Using Genetically Engineered Mice
Why the study?
Does the absence of natriuretic peptide receptor guanylyl cyclase-A worsen mortality and cardiac remodeling after myocardial infarction in mice?
Population
Knockout mice lacking the natriuretic peptide receptor guanylyl cyclase-A, wild-type mice, and double-KO…
Comparison
Genetic knockout of natriuretic peptide receptor… vs Wild-type (WT) mice.
Design
Preclinical
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
These murine results should not guide clinical decisions; extends evidence that GC-A protects against post-MI heart failure and remodeling.
Structured PICO
Does the absence of natriuretic peptide receptor guanylyl cyclase-A worsen mortality and cardiac remodeling after myocardial infarction in mice?
P
Population
Knockout (KO) mice lacking the natriuretic peptide receptor guanylyl cyclase-A, wild-type (WT) mice, and double-KO mice lacking guanylyl cyclase-A and angiotensin II type 1a receptors, subjected to left coronary artery ligation.
I
Intervention
Genetic knockout of natriuretic peptide receptor guanylyl cyclase-A (and double knockout with angiotensin II type 1a receptors).
C
Comparator
Wild-type (WT) mice.
O
Outcome
Mortality after induction of myocardial infarction.hard clinical
Guanylyl cyclase-A activation by endogenous cardiac natriuretic peptides protects against acute heart failure and attenuates chronic cardiac remodeling after myocardial infarction.
Cite This Study
Nakanishi et al. (2005) studied this question.