Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1997Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Natriuretic Peptide Family as a Novel Antimigration Factor of Vascular Smooth Muscle Cells

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do natriuretic peptides inhibit the migration of cultured rat vascular smooth muscle cells?

Population

Cultured rat vascular smooth muscle cells (SMCs)

Comparison

Natriuretic peptide family (rat ANP, rat BNP-45… vs Control (Fetal calf serum or platelet-derived…

Design

Preclinical

Authors

MIMiwako IkedaTokyo Medical and Dental UniversityMKMasakazu KohnoTokyo Rosai HospitalKYKenichi YasunariOsaka City University

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for natriuretic peptides in atherosclerosis prevention; requires in vivo and human studies before clinical consideration.

Structured PICO

Do natriuretic peptides inhibit the migration of cultured rat vascular smooth muscle cells?

P
Population
Cultured rat vascular smooth muscle cells (SMCs)
I
Intervention
Natriuretic peptide family (rat ANP(1-28), rat BNP-45, and rat CNP-22)
C
Comparator
Control (Fetal calf serum (FCS) or platelet-derived growth factor (PDGF)-BB stimulated migration without natriuretic peptides)
O
Outcome
SMC migration measured using Boyden's chamber methodssurrogate

Natriuretic peptides, particularly CNP-22, inhibit vascular smooth muscle cell migration via a cyclic GMP-dependent process, suggesting a potential role in preventing atherosclerosis progression.

Cite This Study

Ikeda et al. (1997) studied this question.

synapsesocial.com/papers/6a83a65720cfb2932ffe1853https://doi.org/10.1161/01.atv.17.4.731
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phorbol ester and atrial natriuretic peptide receptor response on vascular smooth muscle.1992 · 34 citations
  2. 2Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.1989 · 2,172 citations
  3. 3Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)1991 · 734 citations
  4. 4Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.1991 · 1,363 citations
  5. 5Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells1982 · 336 citations