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Specific determinations of cortisone/cortisol in the maternal and cord blood at the time of delivery in 9 normal pregnant women, 2 patients with adrenogenital syndrome, and 1 patient with Addison's disease showed that the cortisone/cortisol ratio was altered from 1:10 in the maternal blood to more than 1:1 in cord blood, presumably due to transhydrogenation in the placenta. The significance of the alteration in the cortisone/cortisol ratio from mother to infant is discussed.
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Bro‐Rasmussen et al. (1962) studied this question.
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