Why the study?
Do ApoB, LDL-C, and ApoB/ApoA-1 ratio correlate with a family history of very early myocardial infarction in children?
Do ApoB, LDL-C, and ApoB/ApoA-1 ratio correlate with a family history of very early myocardial infarction in children?
ApoB, LDL-C, and the ApoB/ApoA-1 ratio may be better predictors of cardiovascular risk in children with a family history of very early myocardial infarction compared to ApoA-1, HDL-C, and LDL/ApoB.
ApoB and related ratios may refine early risk assessment in children with familial MI history; leaves open whether they improve outcomes or warrant routine use.
AIM: The relationship between apolipoprotein B, LDL/ApoB, ApoB/ApoA-1, lipids and a family history of very early myocardial infarction (parent and/or grandparent <45 years) was studied in 46 children compared with 64 controls. METHODS: 19 children came out of families with a myocardial infarction (MI) of the father and 27 children with MI of a grandparent. RESULTS: In the whole risk group LDL-C, ApoB and ApoB/ApoA-1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL-C and LDL/ApoB. CONCLUSION: Our results show that levels of ApoB, LDL-C and ApoB/ApoA-1 might be better predictors in children from families of very early MI as compared with ApoA-1, HDL-C and LDL/ApoB.
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Dirisamer et al. (2006) studied this question.
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