Key result
Type 1 diabetes in children is linked to ~37 mg/dL higher apoB levels.
Why the study?
The offspring of individuals with premature myocardial infarction are at increased risk, but parent/offspring associations of coronary risk factors in affected families versus controls were unclear.
Case-Control (n=90)
Simple random sampling
Absolute Event Rate: 127% vs 90%
p-value: p=<0.05
May support earlier apoB screening in pediatric type 1 diabetes; leaves open links to long-term events.
BACKGROUND: The offspring of individuals with a history of premature myocardial infarction are at increased risk of premature coronary attacks. The aim of this study was to determine parent/offspring associations of coronary risk factors in families affected by premature myocardial infarction and to compare these to corresponding control families. METHODS: The cohort of cases consisted of 71 male survivors of myocardial infarction and their 128 descendants (aged 7-18 years). As control families, 85 randomly selected healthy males with their 66 descendants were investigated. Besides traditional risk factors, serum high sensitive C-reactive protein (hsCRP), apolipoprotein (apo) E phenotypes and lipoprotein(a) were analyzed. RESULTS: In the offspring of the patients, fibrinogen and atherogenic lipoprotein parameters were higher than in the corresponding controls, but hsCRP, lipoprotein(a) and anthropometric data did not differ between the groups. The adult-offspring positive correlations were detected in fibrinogen and in almost all measured lipoprotein fractions in the affected families; amongst the controls, the association was observed only for triglyceride levels. Multiple logistic regression analysis demonstrated independent association of offspring apoB, apoA-I and fibrinogen levels with a family history of premature myocardial infarction. CONCLUSIONS: The most informative predictors of future coronary attacks during childhood are apoB-100 and apoB/apoA-I ratio; serum hsCRP and lipoprotein(a) do not have predictive value in childhood.
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Aasvee et al. (2008) conducted a case-control in Type 1 Diabetes Mellitus risk / Diabetic dyslipidemia (n=90). Type 1 diabetes vs. Healthy children with nondiabetic parents was evaluated on Mean serum apoB levels (p=<0.05). Children with type 1 diabetes had significantly higher mean serum apoB levels compared to healthy children with nondiabetic parents (127 mg/dL vs 90 mg/dL, P<0.05).
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