Key result
Family history of early MI linked to higher atherogenic lipoprotein profiles across all family members.
Why the study?
Differences in the atherogenic lipoprotein profile between families with and without early myocardial infarction history were not fully characterized.
Comparison
Families with early MI history vs families without premature CAD history
Design
Case-control study
Authors
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May support lipid assessment in relatives of early MI patients; leaves open whether esterification rate refines risk stratification.
Case-Control (n=240)
No
Absolute Event Rate: 25.85% vs 20.8%
p-value: p=<0.01
Members of families with a history of early myocardial infarction exhibit a more atherogenic lipoprotein phenotype, which may be influenced by both genetic and shared environmental factors.
Dobiášová et al. (2001) conducted a case-control in Early Myocardial Infarction (n=240). Family history of early myocardial infarction vs. No family history of premature coronary artery disease was evaluated on Fractional esterification rate of cholesterol in HDL plasma (FERHDL) in probands (p=<0.01). A family history of early myocardial infarction was associated with a significantly higher atherogenic lipoprotein profile, indicated by elevated fractional esterification rates of cholesterol in HDL plasma across all family members.
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