Key result
In individuals without clinical atherosclerosis, elevated CRP levels (>0.33 mg/L) were independently associated with a positive family history of myocardial infarction (OR 1.75; 95% CI 1.05-2.91).
Why the study?
Are elevated CRP levels associated with a family history of myocardial infarction in individuals without clinical evidence of atherosclerosis?
Population
1048 individuals without clinical evidence of atherosclerosis
Design
Cross-sectional
Authors
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Elevated CRP may mark heritable MI risk; hypothesis-generating, prospective trials needed before any screening role.
Cohort (n=1,048)
Are elevated CRP levels associated with a family history of myocardial infarction in individuals without clinical evidence of atherosclerosis?
Odds Ratio: 1.75 (95% CI 1.05–2.91)
Elevated CRP levels independently identify offspring of patients with a myocardial infarction, suggesting a potential familial basis for inflammation in cardiovascular risk.
Margaglione et al. (2000) conducted a cohort in Family history of myocardial infarction (n=1,048). Elevated C-reactive protein (>0.33 mg/L) vs. Lower C-reactive protein (≤0.33 mg/L) was evaluated on Positive family history of myocardial infarction (OR 1.75, 95% CI 1.05 to 2.91). In individuals without clinical atherosclerosis, elevated CRP levels (>0.33 mg/L) were independently associated with a positive family history of myocardial infarction (OR 1.75; 95% CI 1.05-2.91).
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