Why the study?
Does interleukin-6 stimulate endothelial binding and transport of HDL through induction of endothelial lipase in cultivated primary endothelial cells?
Does interleukin-6 stimulate endothelial binding and transport of HDL through induction of endothelial lipase in cultivated primary endothelial cells?
Interleukin-6 enhances the first step of reverse cholesterol transport by upregulating endothelial lipase, facilitating HDL translocation across the endothelium.
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IL-6 may enhance endothelial HDL transport via EL in vitro; hypothesis-generating and requires in vivo confirmation before clinical relevance.
Robert et al. (2013) studied this question.
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