Population
19 Sprague-Dawley rats
Comparison
Chronic infusion of the alpha 1-adrenergic… vs Vehicle control infusion during the same 16-day…
Design
Preclinical
Follow-up
16 days
Authors
Loading...
Does not support changes to alpha-1 blocker use; hypothesis-generating for sympathetic roles in salt-sensitive hypertension.
Chronic alpha-1 adrenergic blockade with prazosin causes salt-sensitive hypertension in a rat model, suggesting impaired sympathetic responsiveness plays a role in salt sensitivity.
Osborn et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: