What question did this study set out to answer?

To determine whether the multidrug resistance (mar) regulatory operon identified in Escherichia coli is conserved and functional in other bacterial species.

August 1, 1993The Journal of Infectious Diseases

A Multidrug Resistance Regulatory Chromosomal Locus Is Widespread among Enteric Bacteria

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Authors

SCStan CohenLondon School of Economics and Political Science WYW YanNational Pingtung University of Science and Technology SLStuart B. LevyFederation University

Discussion

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Overview

Laboratory study reveals widespread conservation and activation of the mar operon across enteric bacteria, highlighting a common regulatory pathway for multidrug resistance.

Key Points

To determine whether the multidrug resistance (mar) regulatory operon identified in Escherichia coli is conserved and functional in other bacterial species.
Screened bacterial strains representing 53 species and 27 genera using a mar-specific DNA probe under high-stringency hybridization conditions.
Selected multidrug-resistant mutants of Enterobacter agglomerans and Salmonella species and analyzed them for mar-specific RNA expression.
High-stringency hybridization detected mar-homologous DNA sequences in six additional Enterobacteriaceae genera: Salmonella, Shigella, Klebsiella, Citrobacter, Hafnia, and Enterobacter.
Selected multidrug-resistant mutants of Enterobacter agglomerans and Salmonella species showed increased levels of mar-specific RNA transcription.

Cite This Study

Cohen et al. (1993) studied this question.

synapsesocial.com/papers/6a83bd9ca91c8d236ee6588e https://doi.org/10.1093/infdis/168.2.484

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August 1, 1993The Journal of Infectious Diseases

A Multidrug Resistance Regulatory Chromosomal Locus Is Widespread among Enteric Bacteria

View Full Paper

Ask AI

Bookmark

Authors

SCStan CohenLondon School of Economics and Political Science WYW YanNational Pingtung University of Science and Technology SLStuart B. LevyFederation University

Discussion

Member takes

Overview

Laboratory study reveals widespread conservation and activation of the mar operon across enteric bacteria, highlighting a common regulatory pathway for multidrug resistance.

Key Points

To determine whether the multidrug resistance (mar) regulatory operon identified in Escherichia coli is conserved and functional in other bacterial species.
Screened bacterial strains representing 53 species and 27 genera using a mar-specific DNA probe under high-stringency hybridization conditions.
Selected multidrug-resistant mutants of Enterobacter agglomerans and Salmonella species and analyzed them for mar-specific RNA expression.
High-stringency hybridization detected mar-homologous DNA sequences in six additional Enterobacteriaceae genera: Salmonella, Shigella, Klebsiella, Citrobacter, Hafnia, and Enterobacter.
Selected multidrug-resistant mutants of Enterobacter agglomerans and Salmonella species showed increased levels of mar-specific RNA transcription.

Cite This Study

Cohen et al. (1993) studied this question.

synapsesocial.com/papers/6a83bd9ca91c8d236ee6588e https://doi.org/10.1093/infdis/168.2.484

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