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October 1, 1993Journal of Cardiovascular Pharmacology

Receptor Mechanism of Thrombin-Induced Endothelium-Dependent and Endothelium-Independent Coronary Vascular Effects in Dogs

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Population

isolated canine coronary arteries with and without intact endothelium

Design

Preclinical

Authors

DKDavid D. KuUniversity of Alabama at BirminghamJZJoanne K. ZaleskiUniversity of Alabama at Birmingham

Discussion

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Implication

Endothelium status dictates opposing TRAP vascular effects in this model; extends mechanistic insights but leaves open human translation.

Structured PICO

P
Population
isolated canine coronary arteries with and without intact endothelium
I
Intervention
thrombin receptor agonist peptide (TRAP) 0.01–3.0 μM
O
Outcome
vascular relaxation and contraction responsessurrogate

The opposing coronary vascular effects of thrombin (endothelium-dependent relaxation and endothelium-independent contraction) are mediated by the same receptor mechanism.

Cite This Study

Ku et al. (1993) studied this question.

synapsesocial.com/papers/6a83cf468df3fed3c85bd687https://doi.org/10.1097/00005344-199310000-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Thrombin-Induced Endothelium-Dependent Coronary Vasodilation in Dogs: Role of its Proteolytic Enzymatic Activity1986 · 39 citations
  2. 2Distinct receptors and signaling pathways in alpha-thrombin- and thrombin receptor peptide-induced vascular contractions.1994 · 31 citations
  3. 3Thrombin causes endothelium‐dependent biphasic regulation of vascular tone in the porcine renal interlobar artery2000 · 45 citations
  4. 4Inhibition of Thrombin-Induced Endothelium-Dependent Relaxation After Coronary Ischemia in the Dog1991 · 11 citations
  5. 5Coronary Vascular Reactivity After Acute Myocardial Ischemia1982 · 329 citations