Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 2000British Journal of PharmacologyOpen Access

Thrombin causes endothelium‐dependent biphasic regulation of vascular tone in the porcine renal interlobar artery

View Full Paper
Ask AI
Bookmark
Share

Population

Porcine renal interlobar arterial strips

Comparison

Thrombin and protease-activated… vs Endothelium-denuded strips, or strips treated…

Design

Preclinical

Authors

DDDmitry N. DerkachArizona State UniversityEIEikichi IharaKyushu UniversityKHKatsuya HiranoKagawa University

Discussion

Loading...

Member takes

Implication

Thrombin biphasically modulates porcine renal arterial tone; leaves open whether similar endothelium-dependent mechanisms operate in human kidneys.

Structured PICO

P
Population
Porcine renal interlobar arterial strips
I
Intervention
Thrombin (various concentrations) and protease-activated receptor-1-activating peptide
C
Comparator
Endothelium-denuded strips, or strips treated with antagonists/inhibitors (ONO-3708, OKY-046, L-NAME, high K+)
O
Outcome
Vascular tone (relaxation and contraction) and cytosolic Ca(2+) concentrationsurrogate

Thrombin regulates vascular tone in porcine renal arteries via a biphasic, endothelium-dependent mechanism involving NO, hyperpolarizing factors, TXA2, and PGH2.

Cite This Study

Derkach et al. (2000) studied this question.

synapsesocial.com/papers/6a715bac35aa2c282ce2a8bahttps://doi.org/10.1038/sj.bjp.0703737
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium‐dependent contractile actions of proteinase‐activated receptor‐2‐activating peptides in human umbilical vein: release of a contracting factor via a novel receptor1998 · 47 citations
  2. 2Thapsigargin‐induced endothelium‐dependent triphasic regulation of vascular tone in the porcine renal artery1999 · 21 citations
  3. 3Prostaglandin H2 and thromboxane A2 are contractile factors in intrarenal arteries of spontaneously hypertensive rats.1992 · 67 citations
  4. 4Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly1995 · 451 citations
  5. 5Endothelium-derived vasoactive factors: II. Endothelium-dependent contraction.1991 · 146 citations