Key result
Bradykinin caused endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery, with contraction mediated by TXA2 and PGH2, and relaxation by nitric oxide.
Bradykinin regulates vascular tone in the porcine renal artery through a complex triphasic mechanism involving NO, hyperpolarizing factors, TXA2, and PGH2.
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Does not inform clinical renal vascular management; leaves open translation of porcine bradykinin mechanisms to human disease.
Ihara et al. (2000) studied this question. Bradykinin was evaluated on Changes in cytosolic Ca(2+) concentration and force of smooth muscle. Bradykinin caused endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery, with contraction mediated by TXA2 and PGH2, and relaxation by nitric oxide.
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