Population
Human coronary arterioles (HCA) from right atrial appendages, constricted by 30-50% with endothelin-1
Comparison
Thrombin (10(-4)-1 U/ml) vs Baseline conditions and application of various…
Design
Preclinical
Authors
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May modulate coronary tone via endothelial K+ channels; hypothesis-generating and requires human validation before clinical consideration.
Thrombin dilates human coronary arterioles through an endothelium-dependent mechanism involving potassium channels, independent of nitric oxide and Gi-protein activation.
Bosnjak et al. (2003) studied this question.
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