November 1, 1987Journal of Applied Physiology
Alpha-thrombin-induced pulmonary vasoconstriction
Population
Isolated guinea pig lungs perfused with Ringer albumin (0.5% g/100 ml)
Comparison
Injection of alpha-thrombin (the native enzyme) vs Modified thrombins and inhibitors
Design
Preclinical
Follow-up
up to 90 minutes
Authors
Discussion
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Implication
Hypothesis-generating for thrombin-mediated lung injury; should not yet inform human therapy or trials.
Structured PICO
P
Population
Isolated guinea pig lungs perfused with Ringer albumin (0.5% g/100 ml)
I
Intervention
Injection of alpha-thrombin (the native enzyme)
C
Comparator
Modified thrombins (gamma-thrombin lacking the fibrinogen recognition site or i-Pr2P-alpha-thrombin lacking the serine proteolytic site) and inhibitors (indomethacin, dazoxiben, or hirudin)
O
Outcome
Pulmonary arterial pressure (Ppa) and pulmonary capillary pressure (Ppc)surrogate
Alpha-thrombin induces pulmonary vasoconstriction and edema in isolated guinea pig lungs via the cyclooxygenase pathway, requiring its proteolytic site.
Cite This Study
Horgan et al. (1987) studied this question.