Substance P-induced pulmonary vasoreactivity in isolated perfused guinea pig lung.
Key result
Substance P induces intense pulmonary vasoconstriction and increases fluid filtration without altering vascular permeability.
Population
Isolated Ringer's-perfused and blood-enriched Ringer's-perfused guinea pig lungs, and bovine pulmonary…
Comparison
Substance P (0.01-1.0 microM) vs Baseline/control conditions; also tested with…
Design
Preclinical
Follow-up
30 minutes
Authors
Discussion
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Implication
Substance P may promote fluid filtration via vasoconstriction in experimental lungs; leaves open its role in human pulmonary edema.
Structured PICO
P
Population
Isolated Ringer's-perfused and blood-enriched Ringer's-perfused guinea pig lungs, and bovine pulmonary artery endothelial monolayers
I
Intervention
Substance P (0.01-1.0 microM)
C
Comparator
Baseline/control conditions; also tested with papaverine, meclofenamate, and pyrilamine
O
Outcome
Pulmonary hemodynamics (arterial pressure, capillary pressure, venous resistance) and transvascular fluid filtration (lung weight, capillary filtration coefficient, albumin permeability)surrogate
Substance P induces intense pulmonary vasoconstriction and increases transvascular fluid filtration without altering vascular permeability.
Cite This Study
Selig et al. (1988) studied this question. Substance P was evaluated on Pulmonary hemodynamic and transvascular fluid filtration. Substance P induces intense pulmonary vasoconstriction and elevates pulmonary capillary pressure, increasing net transvascular fluid filtration without affecting vascular permeability.