Convalescent troponin and cardiovascular death following acute coronary syndrome

Figures

• 

  Figure 1. Study profile.

• 

  Figure 2. Trends in troponin concentration over 1 year following acute coronary syndrome. Patients with samples available at all time-points and without recurrent myocardial infarction prior to the 12-month visit were included in this analysis (n=1513). Each individual is represented as a circle coloured according to their troponin concentration at the 1-month study visit. This demonstrates both average and individual change in troponin concentrations over time. The whiskers of the boxplots extend to the highest or lowest values not greater than 1.5 times the IQR of troponin concentrations.

• 

  Figure 3. Cumulative incidence of cardiovascular death according to 4-month troponin concentration Cumulative event curves for cardiovascular death according to troponin concentrations determined at the 4-month visit. Each cross-hair indicates when a subject is censored from further follow-up. The number at risk (% in group remaining) for each yearly interval is given for each troponin group. Follow-up begins from date of 4-month visit. *For descriptive purposes, troponin concentrations have been rounded to nearest integer value. Therefore ≤5 ng/L includes all patients <5.5 ng/L.

• 

  Figure 4. Risk of cardiovascular death at 5 years according to 4-month troponin concentration and relative change in troponin concentration to 12 months. The estimated 5-year risk of cardiovascular death in relation to interval change in troponin concentrations is presented and grouped according to 4-month troponin concentrations (≤5 ng/L—blue, 6 ng/L–99th centile—orange, >99th centile—red). The 95% CIs for these estimates are demonstrated within the correspondingly shaded regions. The rug-plot shown along the x-axis depicts each occurrence of the specific combination of 4-month troponin and relative change to 12 months within the study cohort. For descriptive purposes, troponin concentrations have been rounded to nearest integer value. Therefore, ≤5 ng/L includes all patients <5.5 ng/L. Additional details regarding this statistical model are provided in the online supplementary appendix. CVD, cardiovascular disease.