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January 27, 2012Diabetes CareOpen Access

Effects of Electronegative VLDL on Endothelium Damage in Metabolic Syndrome

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Why the study?

Does highly electronegative VLDL (V5) from patients with metabolic syndrome induce greater endothelial damage compared to VLDL from normal controls?

Population

26 human subjects (13 with metabolic syndrome, 13 normal controls) and human aortic endothelial cells

Comparison

Exposure to charge-defined VLDL subfractions or… vs VLDL from normal control subjects

Design

Preclinical

Authors

CCChu‐Huang ChenGeneral / Preventive / LipidsJLJonathan LuUniversity of ConnecticutSCShuhua ChenCentral South University

Discussion

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Implication

May link V5 to endothelial injury in metabolic syndrome; hypothesis-generating and requires human validation before clinical relevance.

Structured PICO

Does highly electronegative VLDL (V5) from patients with metabolic syndrome induce greater endothelial damage compared to VLDL from normal controls?

P
Population
26 human subjects (13 with metabolic syndrome, 13 normal controls) and human aortic endothelial cells
I
Intervention
Exposure to charge-defined VLDL subfractions (V1-V5) or unfractionated VLDL from patients with metabolic syndrome
C
Comparator
VLDL from normal control subjects
O
Outcome
Percentage of V5 VLDL, plasma V5 concentration, and endothelial cell apoptosis and reactive oxygen species (ROS) productionsurrogate

Highly electronegative VLDL (V5) is elevated in metabolic syndrome and induces rapid reactive oxygen species production and apoptosis in vascular endothelial cells, suggesting a mechanism for vascular injury.

Cite This Study

Chen et al. (2012) studied this question.

synapsesocial.com/papers/6a83d6496eaad3b729ee8b32https://doi.org/10.2337/dc11-1623
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