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January 1, 1998Journal of Hypertension

Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats

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Why the study?

Does neonatal sympathectomy prevent structural vascular changes in angiotensin II-treated rats?

Population

Male Sprague-Dawley rats, aged 3-4 months, neonatally sympathectomized or sham-sympathectomized

Comparison

Angiotensin II 200 ng/kg per min subcutaneously… vs Sham-operated sympathectomized and…

Design

Preclinical

Follow-up

4 weeks

Authors

GSGéza SimonUniversity of MinnesotaBCB. CsikyUniversity of Pecs

Discussion

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Implication

Suggests sympathetic role in large-artery remodeling in ANG II rats; leaves open mechanisms of small-artery changes for further preclinical study.

Structured PICO

Does neonatal sympathectomy prevent structural vascular changes in angiotensin II-treated rats?

P
Population
Male Sprague-Dawley rats, aged 3-4 months, neonatally sympathectomized or sham-sympathectomized
I
Intervention
Angiotensin II 200 ng/kg per min subcutaneously for 4 weeks in neonatally sympathectomized rats
C
Comparator
Sham-operated sympathectomized and sham-sympathectomized rats (controls)
O
Outcome
Morphometric measurements of all segments of the mesenteric arterial tree and tail systolic blood pressuresurrogate

Neonatal sympathectomy attenuates angiotensin II-induced hypertension and structural changes in large arteries, but not the direct trophic structural changes in small resistance arteries.

Cite This Study

Simon et al. (1998) studied this question.

synapsesocial.com/papers/6a83d650b5a613d8fb3e9946https://doi.org/10.1097/00004872-199816010-00012

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of structural vascular changes with subpressor angiotensin II administration in rats1995 · 28 citations
  2. 2Subpressor angiotensin II is a bifunctional growth factor of vascular muscle in rats1992 · 31 citations
  3. 3Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism.1991 · 397 citations
  4. 4Structural Determinants of Vascular Resistance Properties in Hypertension2008 · 81 citations
  5. 5Structure and function of small arteries1990 · 917 citations