December 1, 2003Cardiovascular ResearchOpen Access

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers

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Why the study?

Does oxidative stress and mast cell degranulation drive TNF-alpha release during myocardial reperfusion?

Structured PICO

Does oxidative stress and mast cell degranulation drive TNF-alpha release during myocardial reperfusion?

Population

Isolated rat hearts and human mast cell line HMC-1

Intervention

Degranulation inhibitors (ketotifen or cromoglycate), oxidants (H2O2 or HOCl), reduced glutathione, TACE inhibitor TAPI-2, or o-phenanthroline

Comparator

Control conditions

Outcome

Release of TNF-alpha and TACE dependencysurrogate

TNF-alpha release during myocardial reperfusion is driven by oxidative stress and mast cell degranulation rather than TACE activation, highlighting mast cell stabilizers as a potential therapeutic strategy.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for mast cell stabilization in reperfusion injury; human trials needed before clinical consideration.

Cite This Study

Stefanie Gilles (2003) studied this question.

synapsesocial.com/papers/6a83d7b6580e84c4605bcabf https://doi.org/10.1016/j.cardiores.2003.08.016

View Full Paper

Ask AI

Bookmark

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers

Structured PICO

Discussion

Implication

Cite This Study

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider