January 1, 1998Clinical and Experimental Hypertension

Significant Role of the Increase in Renin-Angiotensin System in Cardiac Hypertrophy and Renal Glomerular Sclerosis in Double Transgenic Tsukuba Hypertensive Mice Carrying Both Human Renin and Angiotensinogen Genes

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Why the study?

Does lisinopril reduce cardiac hypertrophy and renal glomerular sclerosis in Tsukuba hypertensive mice?

Population

Tsukuba hypertensive mice (THM) carrying both human renin and angiotensinogen genes

Comparison

Lisinopril vs Untreated Tsukuba hypertensive mice, C57BL/6…

Design

Preclinical

Authors

TKTatsuya KaiSanden (Japan)HKHirofumi KinoKindai University KSKeiichi SugimuraUniversity of Tsukuba

Discussion

Member takes

Implication

ACE inhibition may protect heart and kidney beyond BP lowering in hypertensive mice; leaves open human translation.

Structured PICO

Does lisinopril reduce cardiac hypertrophy and renal glomerular sclerosis in Tsukuba hypertensive mice?

Population

Tsukuba hypertensive mice (THM) carrying both human renin and angiotensinogen genes

Intervention

Lisinopril

Comparator

Untreated Tsukuba hypertensive mice, C57BL/6 normal control mice, and single gene transferred mice

Outcome

Cardiac hypertrophy (heart to body weight ratio) and renal glomerular sclerosis indexsurrogate

In a double transgenic mouse model of hypertension, lisinopril inhibited cardiac hypertrophy and renal glomerular sclerosis independently of systolic blood pressure reduction.

Cite This Study

Kai et al. (1998) studied this question.

synapsesocial.com/papers/6a83dcbd3a3643f3cd3e9ea4 https://doi.org/10.3109/10641969809053223

Topics

Hypertension management

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Significant Role of the Increase in Renin-Angiotensin System in Cardiac Hypertrophy and Renal Glomerular Sclerosis in Double Transgenic Tsukuba Hypertensive Mice Carrying Both Human Renin and Angiotensinogen Genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Significant Role of the Increase in Renin-Angiotensin System in Cardiac Hypertrophy and Renal Glomerular Sclerosis in Double Transgenic Tsukuba Hypertensive Mice Carrying Both Human Renin and Angiotensinogen Genes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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