Why the study?
Do nitric oxide synthase (NOS) inhibitors improve hemodynamics in patients and animal models with septic shock?
Do nitric oxide synthase (NOS) inhibitors improve hemodynamics in patients and animal models with septic shock?
NOS inhibitors show marked antihypotensive activity and low toxicity in human septic shock, highlighting the limitations of certain animal models in predicting clinical responses.
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May support NOS inhibitor evaluation in human septic shock; leaves open translation from animal models and requires prospective trials.
Kilbourn et al. (1997) studied this question.
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