Key result
NOS inhibition in septic shock is linked to corrected vasoplegic hemodynamics without worsening tissue oxygenation.
Why the study?
The effects of nitric oxide synthase inhibition on tissue oxygenation and hemodynamics in severe septic shock were not well characterized.
Does NOS inhibition improve hemodynamics without deteriorating tissue oxygenation in patients with severe septic shock?
Observational (n=8)
Does NOS inhibition improve hemodynamics without deteriorating tissue oxygenation in patients with severe septic shock?
p-value: p=<0.001
NOS inhibition in severe septic shock corrects vasoplegic hemodynamic disturbances and allows weaning of adrenergic support without deteriorating tissue oxygenation.
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Hypothesis-generating for NOS inhibition in refractory septic shock; prospective trials needed before clinical adoption.
Broccard et al. (2000) conducted an observational in severe septic shock (n=8). NOS inhibitors (L-NAME or L-NMMA) was evaluated on cardiac index (p=<0.001). NOS inhibition in severe septic shock corrected vasoplegic hemodynamics, decreasing cardiac index (P<0.001) and increasing systemic vascular resistance (P<0.01) without worsening tissue oxygenation.
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