Why the study?
Does nitric oxide synthase inhibition with L-NAME restore the vasopressor response to norepinephrine in ovine hyperdynamic sepsis?
Population
8 chronically instrumented sheep with hyperdynamic sepsis induced by continuous endotoxin infusion.
Comparison
Nitric oxide synthase inhibitor L-NAME combined… vs Norepinephrine alone in both nonseptic and…
Design
Preclinical
Authors
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Enhances norepinephrine responsiveness in ovine sepsis; hypothesis-generating and should not change clinical practice.
Does nitric oxide synthase inhibition with L-NAME restore the vasopressor response to norepinephrine in ovine hyperdynamic sepsis?
Nitric oxide synthase inhibition with L-NAME restores the vasopressor response to norepinephrine in a sheep model of hyperdynamic sepsis.
Meyer et al. (1996) studied this question.
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