Why the study?
Does NOS inhibition with L-NAME restore the vasopressor response to norepinephrine in ovine hyperdynamic sepsis?
Population
8 chronically instrumented sheep with hyperdynamic sepsis induced by continuous endotoxin infusion
Comparison
NOS inhibitor NG-nitro-L-arginine methyl ester… vs Norepinephrine administration without prior…
Design
Preclinical
Authors
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NOS inhibition may augment norepinephrine responsiveness in sepsis; leaves open translation from ovine models to clinical care.
Does NOS inhibition with L-NAME restore the vasopressor response to norepinephrine in ovine hyperdynamic sepsis?
NOS inhibition with L-NAME restores the vasopressor response to norepinephrine in a sheep model of hyperdynamic sepsis.
Meyer et al. (1996) studied this question.
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