Population
40 rats (n=20 on 5% cholesterol diet, n=20 on normal diet)
Comparison
Balloon-induced endothelial denudation of… vs Normal-diet rats and baseline pre-denudation state
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports ET-1 role in neointimal hyperplasia after injury; leaves open whether blockade reduces restenosis in patients.
Endothelin-1 is involved in balloon-induced neointima formation and is produced by both endothelial and neointimal smooth muscle cells in hypercholesterolemic rats.
Kiuchi et al. (2000) studied this question.
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