December 1, 2001Cardiovascular ResearchOpen Access

Administration of exogenous endothelin-1 following vascular balloon injury: early and late effects on intimal hyperplasia

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Why the study?

Does exogenous endothelin-1 stimulate neointimal hyperplasia following arterial balloon angioplasty in a rabbit model?

Population

31 rabbits subjected to arterial balloon angioplasty (BA)

Comparison

Subcutaneous endothelin-1 500 pmol/kg/day for 1… vs Placebo time-release pellets

Design

Preclinical, randomized

Follow-up

10 weeks

Authors

ABAlan BaroletUniversity Health Network

Discussion

Member takes

Implication

Transient ET-1 effects on rabbit neointimal hyperplasia warrant no clinical extrapolation; leaves open its role in human restenosis.

Structured PICO

Does exogenous endothelin-1 stimulate neointimal hyperplasia following arterial balloon angioplasty in a rabbit model?

Population

31 rabbits subjected to arterial balloon angioplasty (BA)

Intervention

Subcutaneous endothelin-1 (ET-1) 500 pmol/kg/day for 1 week via time-release pellets

Comparator

Placebo time-release pellets

Outcome

Intimal cross-sectional area (CSA) at 1 and 10 weekssurrogate

Exogenous ET-1 acutely but transiently stimulates intimal hyperplasia and extracellular matrix production following arterial balloon injury in a rabbit model.

Cite This Study

Alan Barolet (2001) studied this question.

synapsesocial.com/papers/6a86b036a810ea404bcf7ba0 https://doi.org/10.1016/s0008-6363(01)00431-x

View Full Paper

Ask AI

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Administration of exogenous endothelin-1 following vascular balloon injury: early and late effects on intimal hyperplasia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Administration of exogenous endothelin-1 following vascular balloon injury: early and late effects on intimal hyperplasia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider