June 1, 1996Circulation Research

In Situ Hybridization Reveals Extensive Diversity of K + Channel mRNA in Isolated Ferret Cardiac Myocytes

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Population

Enzymatically isolated myocytes from the sinoatrial node, right and left atria, right and left ventricles…

Design

Preclinical

Authors

MBMulugu V. BrahmajothiDuke University MMMichael J. MoralesUniversity of Idaho SLShuguang LiuXi'an Shiyou University

Discussion

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Implication

Animal mapping of cardiac K+ channel transcripts leaves open human relevance and arrhythmia therapeutic targeting.

Structured PICO

Population

Enzymatically isolated myocytes from the sinoatrial (SA) node, right and left atria, right and left ventricles, and interatrial and interventricular septa of ferret hearts

Intervention

In situ hybridization using fluorescent labeled oligonucleotide probes

Outcome

Identity, regional distribution, and cellular distribution of voltage-sensitive K+ channel mRNA subunitssurrogate

The molecular diversity of K+ channel mRNA in the heart is extensive and varies significantly between individual cells and major anatomic regions.

Cite This Study

Brahmajothi et al. (1996) studied this question.

synapsesocial.com/papers/6a83f3afb5a613d8fb3e9d28 https://doi.org/10.1161/01.res.78.6.1083

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In Situ Hybridization Reveals Extensive Diversity of K + Channel mRNA in Isolated Ferret Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In Situ Hybridization Reveals Extensive Diversity of K + Channel mRNA in Isolated Ferret Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider