What question did this study set out to answer?

To identify the molecular basis of species-specific cardiac repolarizing potassium currents and arrhythmia susceptibility by comparing channel subunit expression across rabbits, guinea pigs, and humans.

October 1, 2003AJP Heart and Circulatory Physiology

Molecular basis of species-specific expression of repolarizing K+currents in the heart

View Full Paper

Ask AI

Bookmark

Authors

SZStephen ZichaMuscular Dystrophy Association IMIsaac L. MossUniversity of Connecticut BABruce G. AllenMontreal Heart Institute

Discussion

Member takes

Implication

Species differences in Kv subunits urge caution extrapolating rabbit/guinea pig arrhythmia models to humans; leaves open identification of optimal translational species.

Key Points

To identify the molecular basis of species-specific cardiac repolarizing potassium currents and arrhythmia susceptibility by comparing channel subunit expression across rabbits, guinea pigs, and humans.
Quantified mRNA and protein expression of voltage-gated potassium channel subunits in cardiac tissue from rabbits, guinea pigs, and humans.
Kv1.4, Kv4.2, and Kv4.3 mRNA was present in rabbits but completely undetectable in guinea pig myocardium.
MinK mRNA in guinea pigs was ~3-fold higher than in humans and 20-fold higher than in rabbits, with protein levels ~2-fold higher than in humans and 6-fold higher than in rabbits.
KvLQT1 protein expression in humans was increased by approximately 2-fold versus rabbits and 7-fold versus guinea pigs, while ERG1 mRNA was also highest in human hearts.

Cite This Study

Zicha et al. (2003) studied this question.

synapsesocial.com/papers/6a703815f44fa9f079ddc9c5 https://doi.org/10.1152/ajpheart.00346.2003

View Full Paper

Ask AI

Bookmark

Implication

Species differences in Kv subunits urge caution extrapolating rabbit/guinea pig arrhythmia models to humans; leaves open identification of optimal translational species.

Molecular basis of species-specific expression of repolarizing K+currents in the heart

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular basis of species-specific expression of repolarizing K+currents in the heart

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider