Why the study?
Does age affect cutaneous vasoconstrictor responsiveness to exogenous norepinephrine when endogenous release is antagonized?
Population
Older and young human subjects
Comparison
Intradermal perfusion of 7 doses of… vs Control microdialysis probe site and young…
Design
Cross-sectional
Authors
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Supports reduced cutaneous NE responsiveness in older adults during sympathetic blockade; hypothesis-generating for presynaptic mechanisms in age-related autonomic changes.
Does age affect cutaneous vasoconstrictor responsiveness to exogenous norepinephrine when endogenous release is antagonized?
Cutaneous vasoconstrictor responsiveness to exogenous norepinephrine is decreased in older subjects when endogenous norepinephrine release is blocked, suggesting profound age-related differences in presynaptic norepinephrine release.
Wilson et al. (2004) studied this question.
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