Why the study?
Does prostaglandin E2 vaginal pessary improve labor outcomes compared to amniotomy and oxytocin infusion in pregnant women undergoing induction of labor?
Does prostaglandin E2 vaginal pessary improve labor outcomes compared to amniotomy and oxytocin infusion in pregnant women undergoing induction of labor?
Prostaglandin E2 vaginal pessaries improve labor outcomes, including reducing cesarean sections and postpartum hemorrhage, compared to conventional amniotomy and oxytocin infusion.
May support PGE2 in induction protocols; leaves open superiority versus standard methods pending randomized trials.
Prostaglandin E2 vaginal pessaries (3 mg) were compared with conventional amniotomy and oxytocin infusion as a method of induction of labor in 160 patients in the study group compared with 160 in the control group. Each group consisted of 100 primigravidae and 60 multigravidae. When the features of labor, delivery and fetal status were analyzed for the study and the control groups, the patients who received PGE2 pessaries had a better outcome. The difference was more significant for those patients with a low Bishop score. Compared with controls, the PGE2-treated patients had fewer cesarean sections either for failed induction or fetal distress (P less than 0.01); the incidence of infants with low Apgar score was significantly less (P less than 0.05) and there were fewer postpartum haemorrhages (P less than 0.01).
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Varma et al. (1983) studied this question.
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