Why the study?
Does oral prostaglandin E2 improve labor induction intervals compared to i.v. oxytocin in pregnant females with postmaturity?
Does oral prostaglandin E2 improve labor induction intervals compared to i.v. oxytocin in pregnant females with postmaturity?
Oral PGE2 and i.v. oxytocin result in similar induction-delivery intervals for post-term labor induction, despite oxytocin achieving faster labor establishment.
Similar induction-delivery intervals suggest no clear advantage for oral PGE2 in postmaturity; leaves open need for RCTs before practice change.
Induction of labor was performed in 20 pregnant females with postmaturity (greater than 294 days) using either oral PGE2 tablets (0.5 mg) or i.v. oxytocin drip (each group n = 10). The induction-establishment interval was significantly shorter in the oxytocin group (P less than 0.005). Moreover, the uterine activity (in Alexandria units) at 3 h post-induction and at the end of the first stage of labor, was significantly higher with i.v. oxytocin (P less than 0.005). However, the induction-delivery interval did not differ in both groups. All cases delivered spontaneously with a satisfactory Apgar score.
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Ismail et al. (1989) studied this question.
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